Efficacy Studies

Clinical Field Study

ENTYCE®(capromorelin oral solution) Treated Dogs Demonstrated Significant Increases in Appetite

Results showed a significantly higher proportion of clinically inappetent dogs that received ENTYCE had increased appetite over dogs receiving placebo.1

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Owner Appetite Assessment

Treatment success–single-ques>on assessment %*68.644.60.0078
Treatment success–owner appe>te assessment, %**
Percent change in owner appe>te assessment, mean (±SD)73.3 (±75.9)37.6 (±53.9)0.0125
Percent change in body weight, mean (±SD)1.83 (±2.75)0.11 (±3.61)0.0004
*A dog was considered a treatment success if the owner answered that their dog’s appe>te was increased in response to the ques>on, “Do you feel that during the study (over the 4 ± 1 days of treatment) your dog’s appe>te was increased, no change or decreased?”
**Treatment success was defined as an increase in total score ≥5 from day 0 to day 3 ± 1 (scoring scale 5-25)

Laboratory Effectiveness Study

ENTYCE treated dogs demonstrated significantly increased food consumption compared to dogs that received placebo

Results demonstrated that ENTYCE-treated dogs had a 61% increase in food consumption vs. reduction of 11% in placebo-treated dogs (P< 0.001).2

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Clinical References

Your convenient one-stop source for viewing clinical studies and expert insights.


In-Clinic Tools

Use these downloadable tools for identifying inappetence in dogs and how to use ENTYCE.


Professional Education

Browse a series of short videos tolearn about managing inappetence in dogs with chronic medical conditions with ENTYCE.



  1. Zollers B, Wofford JA, Heinen E, Huebner M, Rhodes L. A Prospective, Randomized, Masked, Placebo-Controlled Clinical Study of Capromorelin in Dogs with ReducedAppetite. J Vet Intern Med. 2016;30(6):1851-1857.
  2. Zollers B, Rhodes L, Heinen E. Capromorelin oral solution increases food consumption and body weight when administered for 4 consecutive days tohealthy adult Beagle dogs in a randomized, masked, placebocontrolled study. BMC Vet Res. 2017; 13:10.