Mechanism of Action

ENTYCE® (capromorelin oral solution) is a ghrelin receptor agonist that mimics the effect of ghrelin the “hunger hormone.” Like naturally occurring ghrelin, ENTYCE binds to specific cell receptors and affects signaling in the hypothalamus, causing the feeling of hunger.

Read more about how ENTYCE effectively stimulates appetite to improve food consumption and has demonstrated safety for long-term use.1,2

Mechanism of Action

Video transcript

Clinical References

Your convenient one-stop source for viewing clinical studies and expert insights.


In-Clinic Tools

Use these downloadable tools for identifying inappetence in dogs and how to use ENTYCE.


Professional Education

Browse a series of short videos tolearn about managing inappetence in dogs with chronic medical conditions with ENTYCE.



  1. Zollers B, Wofford JA, Heinen E, Huebner M, Rhodes L. A Prospective, Randomized, Masked, Placebo-Controlled Clinical Study of Capromorelin in Dogs with Reduced Appetite. J Vet Intern Med. 2016;30(6):1851-1857.
  2. Zollers B, Huebner M, Armintrout G, Rausch-Derra LC, Rhodes L. Evaluation of the safety in dogs of long-term, daily oral administration of capromorelin, a novel drug for stimulation of appetite. J Vet Pharmacol Ther. 2017 Jun;40(3):248-255.