Your Veterinarian Can Help Get Your Dog Eating.

When your dog stops eating, it can be the first sign – and may be the only sign – that your dog is sick. Decreased appetite, also referred to as inappetence, can lead to serious nutritional issues and could be perceived as a sign of suffering.

ENTYCE® (capromorelin oral solution) is the only FDA-approved appetite stimulant for dogs. ENTYCE works like your dog’s naturally-occurring “hunger hormone” to trigger the feeling of hunger, leading your dog to eat. ENTYCE has been researched in clinical studies and found to be safe and effective for stimulating appetite.

ENTYCE is a prescription product that can help stimulate your dog’s appetite while your veterinarian is diagnosing or treating the health condition causing the inappetence.

Notice changes in your dog’s appetite?

Understanding Inappetence

Inappetence is defined as a reduction in or lack of appetite. It may be associated with a variety of conditions or diseases and can be challenging to treat. Early clinical intervention is important to prevent subsequent loss of body weight and complications.

There are varying levels of inappetence, including decreased appetite, changes in appetite, and refusal to eat any food, which all can lead to drastic weight loss.

It is important to monitor and address changes in your dog’s eating behavior since inadequate nutritional intake can result in long-term complications, including impaired quality of life.

Signs of inappetence may include:

  • Decreased interest in or enthusiasm for food
  • Weight loss
  • Muscle wasting
  • Lip smacking
  • Poor hair coat

There are many potential causes of inappetence in dogs, including both chronic and acute medical conditions, medications and psychological problems (e.g., stress or changes in routine, environment or diet).1

Treatment Options

The primary goals in managing inappetence are to diagnose and treat the underlying disease and reinstate adequate nutrition by stimulating appetite.1

The therapeutic approach to inappetence includes:

  • Removing or modifying any medications that may be causing inappetence
  • Removing or modifying any environmental stressors
  • Administering appetite-stimulating therapy

The use of an appetite stimulant may be recommended by a veterinarian during the initial diagnostic work-up while the cause of inappetence is being investigated.2

ENTYCE is the only FDA-approved appetite stimulant for use in dogs.

1Ettinger SJ, Feldman EC. Textbook of Veterinary Internal Medicine. Vol 1. 7th ed. St. Louis, MO: Saunders Elsevier; 2010.
2 Baldwin K, et al. AAHA nutritional assessment guidelines for dogs and cats. J Am Anim Hosp Assoc. 2010; 46:285–96.

Dosing in 3 Easy Steps

ENTYCE is a flavored oral solution that is convenient to administer once daily.

To give your dog his or her dose:

  1. Gently shake contents of the bottle.
  2. Insert the accompanying syringe into the bottle, turn the bottle upside down and draw out the amount of liquid prescribed by your veterinarian.
  3. Insert the tip of the syringe into your dog’s mouth and gradually press the syringe plunger to dispense the entire dose. Rinse the syringe with water when finished dosing.

IMPORTANT SAFETY INFORMATION: ENTYCE® (capromorelin oral solution) is for use in dogs only. Do not use in breeding, pregnant or lactating dogs. Use with caution in dogs with hepatic dysfunction or renal insufficiency. Adverse reactions in dogs may include diarrhea, vomiting, polydipsia, and hypersalivation. Should not be used in dogs that have a hypersensitivity to capromorelin. Please see the full Precribing Information for more detail.

Has Your Dog’s Appetite Changed?

Take this short survey about your dog’s appetite. Then print and share the results with your veterinarian.

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Pet Owner Frequently Asked Questions

Q: What is ENTYCE?

A:  ENTYCE is an appetite stimulant approved for use in dogs.1

Q: What is the dose of ENTYCE?

A: Your veterinarian will prescribe a dose based on your dog’s weight. The recommended dose is 3 mg/kg (or 1.4 mg/lb) and is given by mouth once a day.1

Q: Can I give my dog ENTYCE every other day or start/stop using it in response to my dog’s appetite?

A: Follow your veterinarian’s instructions on dosing ENTYCE for your dog.

Q: Can I use a lower dose of ENTYCE?

A: You should give your dog the dose prescribed by your veterinarian.

Q: Can I give ENTYCE on food instead of in the mouth?

A: ENTYCE should be administered directly into your dog’s mouth. Make sure food is available after dosing.

Q: Does it matter what time of day I give it?

A: It is best to give ENTYCE to your dog around the same time each day, ideally before their first meal of the day.2

Q: What should I do if I accidentally give more than the recommended one dose of ENTYCE per day?

A: Contact your veterinarian immediately if your dog receives more ENTYCE than the prescribed dose.

Q: Are there any age or weight restrictions with using ENTYCE?

A: No, there are no restrictions on age or weight for using ENTYCE.

Q: How long can I give ENTYCE to my dog?

A: ENTYCE can be used for as long as recommended by your veterinarian.

Q: In what sizes is ENTYCE available?

A: ENTYCE is available in 10 mL, 15 mL and 30 mL bottles with respective syringe sizes of 1 mL, 2.5 mL and 7 mL.

Q: What is the flavor of ENTYCE?

A: ENTYCE has a synthetic vanilla flavor.

Q: Are there any animal or plant proteins in the flavoring agent for ENTYCE? Could these cause an allergic reaction in my dog?

A: Please discuss this concern with your veterinarian. While there are no animal or plant proteins in ENTYCE, hypersensitivity or allergic reactions, while rare, are always a possibility with any drug.

1 ENTYCE® (capromorelin oral solution) [Package Insert]. Leawood, KS. Aratana Therapeutics. 2016.
2 Zollers B., Rhodes L., Smith R., Capromorelin oral solution (ENTYCE®) increases food consumption, body weight, growth hormone, and sustained insulin-like growth factor 1 concentrations when administered to healthy adult beagle dogs; J Vet Pharmacol. Therap. 217 April; 40(2):140-147.

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